情绪失调和刺激药物在成人多动症多动症
Myrto Sklivanioti Greenfield1, Yanlu Wang1, J Paul Hamilton1
1From the Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (Sklivanioti Greenfield, Msghina); the Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden (Wang); Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden (Wang); the Department of Biological and Medical Psychology, University of Bergen, Norway (Hamilton); the Department for Radiology and Medical Physics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); the Center for Experimental and Biomedical Imaging in Örebro, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); and the Department of Psychiatry, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Msghina).
患有注意力缺陷/多动症障碍 (ADHD) 的成年人表现出情绪调节受损,诱导和处理有缺陷. 与对照人群相比,兴奋剂药物没有使ADHD患者的情绪和神经差异正常化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 情绪失调在成人注意力缺陷/多动障碍 (ADHD) 中普遍存在,影响日常功能和并发症.
- 它越来越被认为是ADHD的核心症状.
研究的目的:
- 为了研究成年ADHD患者的情绪失调.
- 探索ADHD情绪失调的神经基础.
- 为了确定兴奋剂药物是否能使ADHD的情绪处理正常化.
主要方法:
- 对比成人多动症患者与健康对照对行为,结构和功能指标.
- 在ADHD患者的刺激挑战前后评估情绪诱导和调节.
- 利用脑成像来分析神经活动和灰质体积.
主要成果:
- 患有ADHD的患者表现出情绪诱导和行为调节能力降低.
- 大脑成像显示了ADHD患者的激活/停活模式的改变以及灰色质量体积的差异.
- 兴奋剂药物没有扭转在情绪处理中观察到的行为或功能缺陷.
结论:
- 成年ADHD患者可能在情绪诱导和调节方面存在固有的缺陷.
- 这些情绪处理障碍不会被兴奋剂药物改善.
- 这些发现对理解和治疗ADHD情绪失调有临床意义.
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