骨质疏松与骨相关的衰老生物标志物相关的骨质疏松,该生物标志物来源于尿蛋白质谱:一项人口研究
Yu-Ling Yu1,2, Dries S Martens3, De-Wei An1,2,4
1Research Unit Environment and Health, KU Leuven Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium.
Aging and disease
|August 9, 2024
概括
一个新的生物标志物,UPPost-age,来自尿蛋白质谱,准确预测骨质疏松风险和骨质疏松性骨折在老年人群. 这一发现为早期查和预防策略提供了一个新的工具.
科学领域:
- 生物化学 生物化学
- 老年学是一门学科.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 骨质疏松症和骨质疏松性骨折对健康造成重大负担.
- 有效的查和预防策略对于管理这种情况至关重要.
研究的目的:
- 构建和验证一个与衰老相关的生物标志物,UPPost-age,从尿蛋白质谱 (UPP) 来进行骨质疏松症预测.
- 评估UPPost-age与骨质疏松症风险和骨折的关联.
主要方法:
- 利用毛细管电泳与质谱相结合,在前性人口研究中分析UPP.
- 在519名参与者的2372个尿上使用弹性回归开发了UPPost-age生物标志物.
- 在衍生和时间移动/同步验证数据集中验证生物标志物.
主要成果:
- 确定了29种 (10种蛋白质) 形成UPPost-age生物标志物,与时间年龄和骨完整性相关.
- UPP-post-age与身体高度与手臂跨度比率负相关,这是骨质疏松症标志物.
- UPPost-age显示骨质疏松症和骨折的10年风险增加,特别是在女性中.
结论:
- 与衰老相关的UPP签名,UPPost-age,是验证的骨质疏松风险生物标志物.
- 在骨质疏松症的查和试验研究中,UPPost-age显示出临床应用的潜力.
- 这种生物标志物提供了一种新的方法来识别患有骨质疏松性骨折风险的个体.
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