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Updated: Jun 17, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

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在CDK2-cyclin A-CDC25A复合体的冷-EM结构

Rhianna J Rowland1, Svitlana Korolchuk1,2, Marco Salamina1,3

  • 1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

Nature communications
|August 9, 2024
PubMed
概括

细胞分裂周期25 (CDC25) 酸酶通过脱化激活循环素依赖激酶 (CDKs). 这项研究揭示了CDK2-cyclin A与CDC25A结合的冷-EM结构,详细介绍了CDK调节和潜在抗癌策略的关键相互作用.

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