基于狂犬病的非活化拉萨热病毒候选疫苗LASSARAB保护非人类灵长类动物免受致命疾病的侵害
Gabrielle Scher1, Catherine Yankowski1, Drishya Kurup1,2
1Department of Microbiology and Immunology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
NPJ vaccines
|August 9, 2024
概括
一种新的拉萨热病疫苗 (LASSARAB) 显示出有前途. 在非人类灵长类动物中,这种基于狂犬病病毒的疫苗可以预防拉萨热病毒的挑战,为这种致命疾病提供了潜在的新工具.
科学领域:
- 病毒学和免疫学 病毒学和免疫学
- 疫苗开发 疫苗开发
- 传染性疾病 传染性疾病
背景情况:
- 拉萨热病毒 (LASV) 在西非引起严重的出血性疾病,对公众健康构成重大威胁.
- 拉斯维是一种CDC一级生物威胁剂,也是世卫组织优先病原体.
- 目前没有FDA授权的疫苗或针对拉萨热的特定疗法.
研究的目的:
- 为了评估新型候选疫苗LASSARAB对拉萨热病的疗效.
- 拉萨拉布 (LASSARAB) 是一种基于失活狂犬病病毒 (RABV) 的疫苗,编码了LASV的葡萄糖蛋白前体 (GPC).
主要方法:
- 非人类灵长类动物 (NHPs) 接受了拉萨拉布两剂方案或基于RABV的对照疫苗.
- 在免疫NHP中评估了对LASV-GPC的幽默免疫反应.
- 接种疫苗和对照NHP随后受到LASV的挑战.
主要成果:
- 用LASSARAB免疫的NHPs对LASV-GPC产生了强大的幽默反应.
- 所有用LASSARAB接种疫苗的NHP都在LASV挑战中幸存下来.
- 对照组中的NHPs没有在LASV挑战中幸存下来.
结论:
- 拉萨拉布候选疫苗在保护NHPs免受拉萨热病的保护方面表现出显著的有效性.
- 拉萨拉布代表了作为拉萨热病疫苗进一步开发的有希望的候选人.
- 这项研究支持了基于RABV的疫苗平台对新出现的传染病的潜力.
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