一项基于细菌学和基因组学对新诊断的肺结核中影响延迟唾液转化因素的研究
Mengdi Pang1,2, Xiaowei Dai2, Nenhan Wang2
1School of Public Health, Capital Medical University, Beijing, China.
Scientific reports
|August 9, 2024
概括
结核病治疗中唾液转化延迟与Mycobacterium结核病基因组变异和药物耐药性的演变有关. 了解这些因素可以改善治疗策略和患者的治疗结果.
科学领域:
- 微生物学和基因组学 微生物学和基因组学
- 传染性疾病 传染性疾病
- 医学研究 医学研究
背景情况:
- 唾液从阳性转化为阴性是抗结核治疗 (ATT) 疗效的关键指标.
- 影响延迟唾液转换的因素需要从细菌学和基因组学角度进一步调查.
研究的目的:
- 调查与ATT2或5个月后延迟唾液转化相关的细菌学和基因组因素.
- 在ATT期间在转化延迟的患者中分析Mycobacterium结核病 (MTB) 的耐药性动态和基因组变异.
主要方法:
- 在北京 (1782名肺结核 (PTB) 患者) 的回顾性研究 (2021-2022).
- 对24对延迟吐转换患者 (DSCP) 和及时吐转换患者 (TSCP) 的案例对应研究.
- 对75种菌株进行了对13种抗结核药物和全基因组测序 (WGS) 的药物敏感性测试 (DST).
主要成果:
- 及时唾液转换患者 (TSCPs) 呈现出更好的治疗结果和较低的初始耐药性.
- 延迟转换患者 (DSCP) 在药物耐药性表型和宿主内部异质性方面表现出动态变化.
- 在DSCP和TSCP之间观察到单核酸多态性 (SNP) 概况的显著差异.
结论:
- 在MTB的细菌学和基因组变异有助于延迟的唾液转化.
- 了解这些动态可以帮助早期发现唾液转化,并指导ATT策略.
- 该研究提供了对治疗期间MTB演变的见解,为个性化治疗方法提供了信息.
相关概念视频
01:26Pulmonary Tuberculosis IV
134
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
134
01:28Pulmonary Tuberculosis V
176
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
176
01:28Pulmonary Tuberculosis II
215
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
215
01:29Pulmonary Tuberculosis I
227
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
227
01:31Pulmonary Tuberculosis III
316
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
316
01:20Sputum Studies II: Culture and Sensitivity
282
Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
282