罕见的功能性胰腺神经内分泌瘤的特征,治疗和结果
Max B Albers1, Martina Sevcik2, Dominik Wiese2
1Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Philipps University Marburg, Marburg, Germany. albersm@med.uni-marburg.de.
Scientific reports
|August 9, 2024
概括
功能性胰腺神经内分泌瘤 (rf-pNENs) 是罕见的. 这项研究分析了12例病例,发现完全切除和没有初始肝脏参与是长期无疾病生存的关键.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 功能性胰腺神经内分泌瘤 (rf-pNENs) 罕见,除胰岛素瘤和胃瘤外.
- 由于数据有限,它们的独特特征和长期预后仍然定义不佳.
研究的目的:
- 介绍单一机构的数据和对rf-pNENs的经验.
- 阐明这些罕见瘤的特征和长期结果.
主要方法:
- 在2002年至2022年期间治疗的12名rf-pNEN患者的回顾性分析.
- 数据包括瘤类型,成像,转移,位置,大小,手术切除和随访结果.
主要成果:
- 在12个rf-pNEN中确定了VIPomas,glucagonomas和calcitoninomas.
- 在11个切除的瘤中,有9个获得了R0状态;在随访时,有6名患者活着,有5名患者没有疾病.
- 无病生存率与R0切除和没有初始肝转移有关.
结论:
- 主要瘤的R0切除对于rf-pNENs的良好结果至关重要.
- 没有初始的肝脏参与显著影响长期无病生存率.
- 了解这些罕见的瘤有助于改进管理策略.
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