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Updated: Jun 17, 2025

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Published on: May 27, 2021

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Polθ:在同类重组缺陷瘤中新兴的合成致命合作伙伴

Tancredi Didier Bazan Russo1, Clarissa Mujacic1, Emilia Di Giovanni1

  • 1Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), Section of Medical Oncology, University of Palermo, 90127, Palermo, Italy.

Cancer gene therapy
|August 9, 2024
PubMed
概括

合成致死性 (SL) 利用癌症的脆弱性. 用Polθ抑制剂准同源修复 (HR) 和甲基中介末端结合 (TMEJ) 等DNA修复途径,为治疗HR缺陷瘤提供了新的策略,包括那些具有BRCA1/2突变的瘤.

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