低唤醒值与患有阻塞性睡眠呼吸暂停的患者上升性网状激活系统的功能连接性改变有关
Jung-Ick Byun1, Geon-Ho Jahng2, Chang-Woo Ryu2
1Department of Neurology, Kyung Hee University College of Medicine, Kyung Hee University Hospital at Gangdong, 892 Dongnam-Ro, Gangdong-Gu, Seoul, 05278, Republic of Korea.
Scientific reports
|August 9, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 改变了大脑连接,特别是在低兴奋值 (LAT) 的患者中. 这项研究揭示了与OSA和LAT相关的特定脑干-皮质路径变化,这表明胆固醇活性发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 医疗成像医学成像
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与大脑干功能障碍有关.
- 低兴奋值 (LAT) 是OSA的一个关键特征,可能涉及大脑连接的改变.
- 上升的网膜激活系统 (ARAS) 途径对于唤醒和睡眠调节至关重要.
研究的目的:
- 与对照者相比,研究OSA患者的脑干核和皮层/皮下区域之间的静止状态功能连接,包括具有和没有LAT的患者.
- 为了确定与OSA相关的特定大脑网络变化以及LAT的存在或不存在.
主要方法:
- 功能磁共振成像 (fMRI) 用于评估静止状态的功能连接.
- 基于种子的连接性分析侧重于三个脑干细胞核: (LC),后背体核 (LDTg) 和腹部体区域 (VTA).
- 参与者包括中度至重度OSA (有或没有LAT) 和健康对照患者.
主要成果:
- 对于 LC 和 LDTg 的组,功能连接在组之间有显著的差异.
- 无论LAT如何,OSA患者的LC-precuneus和LDTg-后 cingulate皮质连接性比对照人群更强.
- 没有LAT的OSA患者比LAT患者表现出更强的LDTg-后带皮质连接,与最小氧和负相关.
结论:
- 在OSA中,低兴奋值与改变的LDTg-后侧环状皮层连接性有关.
- 这些发现表明,胆固醇通路可能导致阻塞性睡眠呼吸暂停的低唤醒值.
- 脑干-皮层功能连接是OSA严重程度和相关特征的潜在生物标志物.
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