在不同的代谢成年人中,HOMA-IR和心脏代谢风险指数之间的相关性:一个横截面研究
Qiyun Lu1,2, Benjian Chen1,2, Anxiang Li1,2
1Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
Acta diabetologica
|August 9, 2024
概括
胰岛素抵抗的恒温模型评估 (HOMA-IR) 是心脏代谢风险和心血管疾病的有价值预测指标,特别是在代谢综合征患者中. 这一发现支持其用于一般人口查.
科学领域:
- 内分泌学和新陈代谢学
- 心血管疾病研究研究
背景情况:
- 胰岛素抵抗是代谢综合征 (MetS) 和心血管疾病 (CVD) 的关键因素.
- 胰岛素抵抗的恒温模型评估 (HOMA-IR) 是一种常见的胰岛素敏感性测量方法.
- 心脏代谢风险指数 (CMRI) 是对代谢和心血管风险因素的综合测量.
研究的目的:
- 探索不同代谢状态的成年人中HOMA-IR和CMRI之间的相关性.
- 评估HOMA-IR在预测心脏代谢风险和心血管疾病方面的实用性.
主要方法:
- 一项涉及1550名中国成年人的横截面研究,分为非MetS (n=628) 和MetS (n=922) 组.
- 使用后勤回归和ROC曲线分析来评估HOMA-IR,CMRI和其他风险因素 (BMI,内脏脂肪指数等) 之间的关系. ) 的情况.
- 在不同的代谢,性别和年龄组进行了分析,以评估HOMA-IR对高CMRI和CVD风险的预测能力.
主要成果:
- 与非MetS组相比,MetS组的HOMA-IR和CMRI显著更高 (P <0.05).与非MetS组相比,MetS组的HOMA-IR和CMRI显著更高.
- 在一般人群,非MetS和MetS个体中,HOMA-IR证明了心血管风险的预测价值.
- 体重指数 (BMI),内脏脂肪指数 (visceral fat index),腰比 (waist-to-hip ratio) 和HOMA-IR被确定为高心血管风险的独立指标,而维生素D显示出潜在的保护作用.
结论:
- HOMA-IR是心血管风险增加的独立风险因素,特别是在代谢综合征患者中.
- 无论代谢综合征状况如何,HOMA-IR可以预测心血管疾病风险升高,因此适用于一般人口查.
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