透皮冠状动脉干预后的输血和临床结果
Jungmin Choi1, Seung-Hwa Lee2, Ki-Hong Choi2
1Department of Digital Health, Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, South Korea.
Scientific reports
|August 9, 2024
概括
穿皮冠状动脉干预 (PCI) 后的输血是常见的,并增加了重大不良临床事件 (MACE) 的风险. 接受输血的患者在PCI后的五年内,MACE风险增加了3.2倍.
科学领域:
- 心脏病学 心脏病学
- 输血医学 输血医学
- 干预心脏病学 干预心脏病学
背景情况:
- 穿皮冠状动脉干预 (PCI) 是冠状动脉疾病的常见程序.
- 输血对PCI后长期结果的作用和影响需要进一步调查.
研究的目的:
- 研究在接受PCI的患者中与输血相关的长期模式和临床结果.
- 评估PCI后输血和重大不良临床事件 (MACE) 之间的关联.
主要方法:
- 对2011年接受PCI与支架的韩国患者全国性注册表的分析 (n=48,786).
- 对5年临床结果的评估,重点关注输血的发病率密度.
- 倾向性得分调整以评估输血与MACE (所有原因死亡,再血管化,危急心血管状况,中风) 的关联.
主要成果:
- 输血的5年发病率密度为每100人年4.74.
- 输血患者年龄较大,临床风险因素较多 (p<0.001).
- 输血与MACE (HR 3.2) 和其他临床事件 (HR 1.5-6.9,p<0.001) 的增加显著相关.
- 在5年内,22.9%的患者接受了输血,MACE风险增加了3.2倍.
结论:
- 在PCI后输血与重大不良临床事件的风险显著增加有关.
- 输血的时间与MACE发病率密度最高的时期相关.
- 这些发现凸显了PCI患者明智的输血策略的重要性.
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