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Updated: Jun 17, 2025

Rapid Generation of Amyloid from Native Proteins In vitro
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Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

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溶剂诱导的粉样蛋白多态性和难以捉摸的3类粉样蛋白拓学的发现

Zsolt Dürvanger1,2, Fruzsina Bencs1,3, Dóra K Menyhárd1,2

  • 1Laboratory of Structural Chemistry and Biology, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/A, H-1117, Budapest, Hungary.

Communications biology
|August 9, 2024
PubMed
概括

设计的蛋白质细分称为聚合易发区域 (APR),可以形成多种类型的粉样晶体. 一个单一的氨基酸变化显著降低了晶体的可变性,显示出对序列,温度和环境的敏感性.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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Protein Folding

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