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人类乳酸脱酶a抑制剂的开发:高通量查,分子动力学模拟和酶活性测定

Yuanyuan Shu1,2,3, Jianda Yue1,2,3, Yaqi Li1,2,3

  • 1The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.

Journal of computer-aided molecular design
|August 9, 2024
PubMed
概括

研究人员确定化合物6是一种有前途的小分子抑制剂,向乳酸脱酶A (LDHA). 这种化合物通过抑制LDHA活性和瘤细胞增殖,显示出开发新的向抗瘤药物的潜力.

关键词:
抗癌药物是一种抗癌药物.癌症的代谢 癌症的代谢乳酸脱酶A是一种乳酸脱酶.分子动力学模拟模型

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Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
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