在老年梅克尔细胞癌患者中,心血管死亡风险高
Jia-Nan Huang1,2, Hai Yu1, Xichun Xia3,4
1Department of Dermatology, The First Affiliated Hospital of Jinan University & Jinan University Institute of Dermatology, Guangzhou, China.
BMC geriatrics
|August 9, 2024
概括
与普通人群相比,老年默克尔细胞癌 (MCC) 患者面临心血管死亡率 (CVM) 的风险明显更高. 优先考虑心血管健康和监测对于这些幸存者来说至关重要.
科学领域:
- 在瘤学瘤学.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 默克尔细胞癌 (MCC) 的研究历来专注于发病率和死亡率.
- 在MCC幸存者,特别是老年人中,心血管死亡 (CVM) 风险仍未得到充分研究.
- 了解CVM至关重要,因为它可能是死亡的重要原因之一.
研究的目的:
- 在被诊断患有默克尔细胞癌 (MCC) 的老年人中评估心血管死亡风险 (CVM).
- 在这个患者群体中识别与CVM相关的风险因素.
主要方法:
- 利用了老年MCC患者的监测,流行病学和最终结果 (SEER) 数据库的数据.
- 使用标准化死亡率 (SMR) 和累积死亡率计算CVM风险.
- 采用Fine-Gray的多变量竞争风险模型来分析CVM的风险因素.
主要成果:
- 在2899名MCC患者中,有16.0%患有CVM;心血管疾病成为第二大死亡原因.
- 患有MCC的患者的CVM风险比一般人群高1.69倍 (SMR: 1.69;95%CI: 1.54-1.86).
- 在动脉,动脉小板和毛细血管疾病中观察到CVM风险的显著升高 (SMR:2.69). 诊断时的年龄和疾病阶段是关键的风险因素,而化疗/放射治疗显示出保护作用.
结论:
- 心血管死亡率 (CVM) 是老年梅克尔细胞癌 (MCC) 患者死亡的重要竞争性原因.
- 患有MCC的幸存者患有CVM的风险较高,因此需要积极主动地进行心血管健康管理.
- 个性化心血管监测和干预对于高风险MCC患者来说至关重要,以改善生存结果.
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