在中国的Omicron浪潮期间,严重和危急的Omicron感染患者的免疫和炎症特征
Yongmei Liu1, Yaping Guo2, Haoting Zhan1
1Department of Clinical Laboratory, State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 No. 1, Shuaifuyuan, Dongcheng District, Beijing, 100010, China.
BMC infectious diseases
|August 9, 2024
概括
患有Omicron变种 (PIWO) 感染的患者经历了严重或危急的疾病,显示出免疫反应受损和过度炎症. 这些发现突出了严重疾病的潜在警告标志物和Omicron感染的不良预后.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- SARS-CoV-2的Omicron变种 (B.1.1.529系) 已经导致全球广泛的感染.
- 了解与不同疾病严重程度的Omicron感染相关的免疫和炎症概况对于预测结果至关重要.
研究的目的:
- 为了研究不同疾病严重程度感染Omicron变种 (PIWO) 的患者的基线免疫和炎症特征.
- 分析住院结果,并确定PIWO中严重疾病和死亡率的风险因素.
主要方法:
- 进行了一项涉及140名住院PIWO的横截面研究.
- 临床数据,SARS-CoV-2抗体,免疫细胞计数 (CD4 +,CD8 +,NK细胞) 和炎症细胞因子 (IL-6,IL-10) 在基线和随访期间进行了评估.
主要成果:
- 严重和危急的PIWO主要是男性,需要机械通风,死亡率更高.
- 在未幸存者中观察到受损的幽默免疫 (较低的抗体标位) 和降低的T细胞计数 (CD3 +,CD4 +).
- 炎症标志物 (IL-6,IL-10) 和特定临床因素 (糖尿病,免疫抑制疗法,血清粉样蛋白A,中性粒细胞数量,乳酸脱酶) 的升高与严重/危急疾病和死亡率有关.
结论:
- 在PIWO中,危急疾病和死亡率的特征是皮质免疫反应受损和过度炎症.
- 免疫细胞和炎症标记物的动态变化为Omicron病理生理学提供了洞察力.
- 识别警告标记可以帮助预测严重疾病和PIWO的不良预后.
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