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在中国重庆的HPV特异性和多种感染以及与宫细胞学相关:一个横截面研究

Qinli Luo¹, Haiyan Zhang², Xianghua Zeng²

¹Chongqing Cancer Multi-Omics Big Data Application Engineering Research Center, Chongqing University Cancer Hospital, 181 Hanyu Road, Shapingba District, Chongqing, 400030, China. m13668488467@163.com.

BMC infectious diseases

|August 9, 2024

概括

特定的人类乳头瘤病毒 (HPV) 基因型如HPV16和HPV33与高度子宫病变有关. 多重HPV感染,特别是在α9物种内,增加HSIL风险,为区域疫苗接种策略提供信息.

科学领域:

妇科妇科医生妇科
病毒学病毒学
在瘤学瘤学.

背景情况:

评估特定的人类乳头瘤病毒 (HPV) 基因型,多种感染和宫细胞学之间的关系至关重要.
HPV 疫苗的保护是类型特定的,需要对共感染的流行病学进行调查.
建立基线数据对于制定HPV疫苗接种策略和管理该地区HPV阳性个体至关重要.

研究的目的:

确定特定的HPV基因型和多种感染与宫细胞学异常之间的相关性.
为了调查常见的HPV类型之间的共感染模式.
为HPV疫苗接种和管理策略提供区域数据.

主要方法:

对来自25572名参与者的3649名HPV阳性女性进行分析,检测15种高风险HPV (HR-HPV) 基因型.
使用ThinPrep细胞学测试 (TCT) 结果和后勤回归来评估细胞学异常的风险.
采用对共感染模式的几率比率 (ORs) 和单个/多个HPV感染和细胞学结果的奇平方测试.

主要成果:

HPV16和HPV33感染与高度状内皮病变 (HSIL) 有积极的相关性.
感染HPV66,HPV51和HPV58与低度状内皮病变 (LSIL) 有关.
与单个感染相比,α9物种内的多种感染与HSIL风险增加有关;特定的共感染,如HPV66/HPV56和HPV39/HPV68,显示出正相关性.

结论:

感染HPV33可能需要与HPV16相似的管理方法.
建议加强对多种α9物种感染的管理.
九价HPV疫苗可能在重庆地区提供增强的保护;未来针对HPV51和HPV66的疫苗可能会被考虑.

关键词:

高风险的HPV病毒多种感染多种感染.这就是为什么TCT是TCT.疫苗疫苗疫苗疫苗

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