长期血液透析对糖尿病视网膜病变的影响,通过扫描源光学连贯性断层扫描血管学观察到
Ke He1, Suijun Liu2, Jingbo Shi2
1Department of Ophthalmology, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, 710018, China.
BMC ophthalmology
|August 9, 2024
概括
血液透析 (HD) 显著影响糖尿病视网膜病变 (DR) 患有末期脏病 (ESKD) 的患者的胸膜厚度,尽管视网膜厚度保持稳定. 长期透析患者与DR需要持续关注,尽管明显的黄斑稳定.
科学领域:
- 眼科医生 眼科 眼科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管科学 心血管科学
背景情况:
- 糖尿病可导致微血管并发症,如糖尿病视网膜病变 (DR) 和糖尿病病变 (DN).
- 糖尿病黄斑 (DME) 可能由DR和DN引起或恶化.
- 血液透析 (HD) 是对DN导致的末期病 (ESKD) 的主要治疗方法.
研究的目的:
- 研究单次血液透析 (HD) 疗程对ESKD的DR患者视网膜和胸膜厚度的直接影响.
- 分析DR特征和DME在长期的HD患者DR和ESKD的流行.
主要方法:
- 一项前性队列研究,涉及44名患有ESKD的DR患者,他们经历了长期的HD.
- 扫描源光学连贯性断层扫描血管学 (SS-OCTA) 用于检查85只眼睛.
- 在HD课程之前和之后分析中枢视网膜厚度 (CRT),中枢视网膜体积 (CRV),亚叶胆道体厚度 (SFCT),亚叶胆道体积 (SFCV).
主要成果:
- 在单次HD治疗后,立即没有观察到CRT或CRV的显著变化.
- 在单次HD治疗后,SFCT和SFCV显著下降 (P<0.001).
- 100%的眼睛显示DR特征,49.41%的眼睛有视网膜新血管化,20%的眼睛有DME (主要是囊性黄斑).
结论:
- 单次的HD疗程会导致胸膜厚度的显著变化,这可能是由于液体的移动.
- 尽管长期透析患者的斑点明显稳定,但ESKD患者的DR需要持续监测.
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