COVID-19与葡萄牙1型糖尿病发病率之间的关联 - - 一项注册研究
Morten Bjerregaard-Andersen1,2,3, Jessica Da Silva4,5,6, Rui Diogo7
1Department of Endocrinology and Nephrology, University Hospital of Southern Denmark, Finsensgade 35, 6700, Esbjerg, Denmark. Morten.Bjerregaard-Andersen2@rsyd.dk.
BMC endocrine disorders
|August 9, 2024
概括
这项研究发现,在COVID-19大流行期间,1型糖尿病 (T1D) 诊断或代谢参数的变化没有显著增加. 糖尿病T1D的发病率保持稳定,葡萄糖水平或糖尿病酸性糖尿病发作没有显著差异.
科学领域:
- 内分泌学 在内分泌学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 病毒性呼吸道感染是1型糖尿病 (T1D) 的潜在触发因素.
- 需要对SARS-CoV-2 (COVID-19) 和新发型T1D之间的关联进行调查.
- 这项研究考察了与葡萄牙COVID-19大流行有关的T1D发病率的时间趋势.
研究的目的:
- 确定COVID-19大流行是否影响了儿童和年轻人新发型1型糖尿病 (T1D) 的发生率.
- 评估主要代谢指标的变化和糖尿病酸症 (DKA) 率在T1D诊断前和期间的变化.
主要方法:
- 来自葡萄牙9个单位 (2017-2022) 的医院数据的回顾性分析.
- 在COVID-19大流行之前 (2017-2019) 和期间 (2020-2022) 的年度新发型T1D病例的比较.
- 在诊断时评估中位数葡萄糖,HbA1c,禁食C-水平和DKA频率.
主要成果:
- 分析了574例新发型T1D病例 (92.3%为儿童);48.4%出现了DKA.
- 从2018年到2021年,在8个中心中没有观察到T1D发病率的显著整体增加.
- 在研究期间,没有发现葡萄糖,HbA1c,禁食C-或DKA频率的显著变化.
结论:
- 在COVID-19大流行期间,1型糖尿病 (T1D) 的发病率与大流行前的几年相比没有显著增加.
- 诊断时的主要代谢参数和糖尿病酸症 (DKA) 的频率保持稳定.
- 研究结果表明,COVID-19并没有显著影响研究人口中的T1D发病率或呈现.
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