胃肠道癌症免疫治疗的最新发展
Xiaoyi Chong1, Yelizhati Madeti1, Jieyuan Cai1
1Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, 52 Fucheng Road, Hai-Dian District, Beijing, 100142, China.
免疫疗法,包括免疫检查点抑制剂 (ICI) 和CAR-T细胞疗法,对胃肠道癌症具有前景. 研究重点是针对晚期食道,胃和结肠直肠癌优化这些治疗方法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 近几十年来,免疫疗法已成为消化道 (GI) 癌症的重要治疗方式.
- 免疫检查点抑制剂 (ICI),特别是针对PD-1和PD-L1,在管理先进和外科手术期间的肠道恶性瘤方面发挥着至关重要的作用.
研究的目的:
- 审查当前免疫治疗肠道癌症的现状.
- 总结关键的研究,最近的进展,以及该领域的未来前景.
- 突出免疫治疗在食道癌 (EC),胃/食道结腺癌 (G/GEJC) 和结肠直肠癌 (CRC) 的应用.
主要方法:
- 对肠道癌症免疫治疗研究的文献综述.
- 对ICI和CAR-T细胞治疗的临床试验数据的分析.
- 综合当前治疗指南和新兴治疗策略.
主要成果:
- 与化疗相结合的抗PD-1是高级G/GEJC,dMMR/MSI-HCRC和高级EC的标准第一线治疗.
- 克劳丁18.2-重定向的化学抗原受体T细胞 (CAR-T) 疗法在肠道癌症的后期设置中显示出潜力.
- 目前正在进行的研究旨在提高肠道瘤免疫治疗的精度和疗效.
结论:
- 免疫疗法,特别是ICI和CAR-T细胞疗法,已经改变了胃肠道癌症的治疗.
- 进一步优化是必要的,以最大限度地提高治疗效益和克服耐药性.
- 未来的方向包括完善治疗策略和探索针对肠道恶性瘤的新型免疫治疗方法.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
07:21Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
Published on: May 2, 2022
相关概念视频
Tumor Immunotherapy
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
