儿科急性淋巴细胞白血病中的急性胰腺炎 (AcuPA研究):波兰全国调查
Anna Morawiak1, Małgorzata Salamonowicz-Bodzioch2, Aleksandra Królak1
1Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Cancers
|August 10, 2024
概括
急性胰腺炎 (AP) 在患有急性淋巴细胞白血病 (ALL) 的儿童中不常见,并且与年龄较大有关. AP不会显著影响生存结果,并且重新暴露于阿斯巴拉金酶是安全的.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 临床研究 临床研究
背景情况:
- 急性淋巴细胞白血病 (ALL) 是一种常见的儿童癌症.
- 阿斯巴拉金酶 (ASP) 是ALL治疗中的关键化疗剂.
- 急性胰腺炎 (AP) 是ASP治疗的已知并发症.
研究的目的:
- 为了确定在接受ALL治疗的波兰儿童中AP发生率.
- 在这个群体中识别AP发展的风险因素.
- 评估AP对治疗结果的影响,包括存活率和阿斯巴拉金酶再暴露.
主要方法:
- 对2303名接受ALL强化化疗的儿童进行了回顾性分析.
- 将患者分为有AP和没有AP的组.
- 统计分析以确定风险因素并比较生存概率 (p-DFS,p-EFS).
主要成果:
- AP的累计发病率为4.08%.
- 高龄是AP的一个独立风险因素 (OR = 1.05;p = 0.03).
- AP没有显著影响无疾病生存率 (p-DFS) 或无事件生存率 (p-EFS).
- 患有AP病史的患者再次接触阿斯巴拉金酶导致复发率低 (4.5%) 并没有影响生存结果.
结论:
- 患有ALL儿童的AP发病率较低,并与患者年龄相关.
- 在患有ALL的儿童中,AP发育不会对p-DFS或p-EFS产生负面影响.
- 在最初的AP插曲后重新暴露于阿斯巴拉基纳是安全的,并且不会恶化生存结果.
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