暴露在夜间的光线和癌症风险:系统性审查,元分析和数据合成
Samuel Ma1, Yossef Alsabawi2, Hashem B El-Serag3,4
1School of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Cancers
|August 10, 2024
概括
夜间暴露于光线 (LAN) 与女性乳腺癌风险增加有关. 需要更多的研究来了解LAN LAN.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 越来越多的证据表明,环境因素,如夜间光线 (LAN),可能会导致癌症的发展.
- 本研究系统地审查了关于LAN暴露与各种癌症类型之间的关联的观察研究.
研究的目的:
- 进行观察性研究的系统审查和元分析,调查夜间 (LAN) 光暴露与癌症风险之间的联系.
- 评估LAN与多种癌症类型之间的关联.
主要方法:
- 在PubMed,Web of Science和Embase进行了全面的文献搜索,截至2023年5月.
- 包括专注于成人群体和LAN暴露的研究. 随机效应模型被用于元分析,研究质量被使用"干预非随机研究中偏差风险"工具评估.
主要成果:
- 在8492项已识别的研究中,有26项符合纳入标准,涵盖了全球不同类型的癌症.
- 对19项乳腺癌研究的元分析显示,室内 (RR 1.08) 和室外 (RR 1.10) LAN暴露率较高与乳腺癌风险增加之间存在积极联系.
- 由于缺乏足够的研究,对其他癌症类型没有发现显著的关联.
结论:
- 夜间照明 (LAN) 暴露与女性患乳腺癌的风险增加有关.
- 关于LAN暴露和其他癌症类型的研究显著缺乏.
- 进一步的研究至关重要,以阐明LAN在各种癌症病因学中的作用.
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