在人类肝癌中delta-tocotrienol的抗癌活性:自诱导的参与
Marina Montagnani Marelli1, Chiara Macchi1, Massimiliano Ruscica1,2
1Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università degli Studi di Milano, 20133 Milan, Italy.
Cancers
|August 10, 2024
概括
作为维生素E的衍生物,三角-托克醇 (δ-TT) 是治疗晚期肝细胞癌 (HCC) 的有前途的药物. 这种化合物通过触发氧化应激和自来诱导癌细胞死亡,从而提供了潜在的新疗法策略.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 细胞生物学 细胞生物学
背景情况:
- 肝细胞癌 (HCC) 是一种主要的肝癌,对于晚期的肝癌,系统性治疗选择有限.
- 目前用于高级HCC的全身疗法通常会导致显著的副作用.
- 维生素E的衍生物,特别是托科特里昂醇 (TTs),表现出已知的抗瘤特性.
研究的目的:
- 为了研究delta-tocotrienol (δ-TT) 对人类肝细胞癌 (HCC) 细胞系的抗瘤活性.
- 分析 δ-TT 诱导细胞死亡的机制,包括细胞亡,氧化应激和自.
- 评估自在调解HCC中 δ-TT的细胞毒性作用中的作用.
主要方法:
- 用 δ-TT.治疗HepG2 HCC细胞系的治疗方法.
- 对亡诱导和氧化应激 (ROS释放) 的评估.
- 分析线粒体形态和功能 (裂变).
- 评估自和小的作用.
- 抑制自,以确定其在细胞死亡中的作用.
主要成果:
- δ-TT对HCC细胞表现出抗增殖和益的作用.
- δ-TT诱导的线粒体活性氧物种 (ROS) 释放和结构变化表明裂变.
- δ-TT触发了选择性自,去除了功能障碍的线粒体.
- 抑制自可以抵消 δ-TT 的细胞毒性作用.
结论:
- δ-TT对HCC细胞表现出显著的抗癌活性.
- 该机制涉及诱导线粒体功能障碍和激活自.
- δ-TT,通过自激活,代表了高级HCC的潜在治疗剂.
更多相关视频
11:13Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
1.5K
00:06An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
8.8K
相关概念视频
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:27Tumor Immunotherapy
497
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
497
01:27Autophagy
4.2K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.2K