关节内氨和自身蛋白质溶液对马的代谢参数的影响
Allen E Page1, Mackenzie Johnson1, Jordan L Parker1
1Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.
Animals : an open access journal from MDPI
|August 10, 2024
概括
马的关节内三素乙化物 (TA) 显著影响了ACTH,皮质醇,葡萄糖和胰岛素水平. 自生蛋白溶液 (APS) 没有显示出这种代谢效应,这表明TA在测试前需要更长的洗期.
科学领域:
- 马类内分泌学 马类内分泌学
- 关节内注射的药理学
背景情况:
- 关节内皮质类固醇广泛用于治疗马类关节疼痛和炎症.
- 这些治疗方法的代谢效应需要进一步研究.
研究的目的:
- 为了比较马体内关节性三氨醇乙化物 (TA) 与自身蛋白溶液 (APS) 的代谢效应.
- 评估对荷尔蒙和葡萄糖/胰岛素参数的影响.
主要方法:
- 五匹马连续接受了液,APS或9毫克TA的内关节治疗.
- 血和血清样本被分析为ACTH,皮质醇,葡萄糖,胰岛素和甲状腺激素.
- 进行了激素释放激素 (TRH) 和口服糖测试 (OSTs).
主要成果:
- 内关节TA显著影响了注射后的ACTH,皮质醇,葡萄糖和胰岛素水平.
- 在TA治疗后观察到ACTH和皮质醇的显著抑制,高血糖和高胰岛素血症.
- 在APS治疗或任何甲状腺激素治疗时,没有发现显著的代谢或激素影响.
结论:
- 关节内TA会在马中引起显著的短期代谢障碍.
- 建议在TA注射和内分泌检测 (TRH/OST) 之间至少有2至7天.
- 在这种马类模型中,APS与TA相比,在代谢上似乎是惰性的.
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