坦卡塞 (Tanacetum balsamita) L.对代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的缓解作用
Rositsa Mihaylova1, Reneta Gevrenova2, Alexandra Petrova1
1Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Sofia 1000, Bulgaria.
Plants (Basel, Switzerland)
|August 10, 2024
概括
塔纳塞姆香草提取物 (ETB) 在大鼠的代谢相关脂肪肝疾病 (MAFLD) 中显示出显著的益处. ETB改善了代谢参数,减少了氧化应激,并预防了肝损伤,表明其对MAFLD的治疗潜力.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 代谢综合征及其并发症是代谢相关脂肪肝疾病 (MAFLD) 的危险因素.
- 草本提取物正在研究它们在治疗MAFLD和相关代谢障碍方面的治疗潜力.
研究的目的:
- 评估Tanacetum balsamita (ETB) 的甲醇水性提取物在小鼠模型中改善MAFLD的疗效.
- 评估ETB对代谢参数,氧化应激和肝功能的影响.
主要方法:
- MAFLD在使用高热量饮食和 estreptozotocin 的老鼠中被诱导.
- 鼠被用150和300毫克/体重每公斤的ETB治疗,其中阿卡尔和阿托瓦斯塔丁作为阳性对照.
- 分析了代谢综合征的生化标志物,氧化应激,肝功能和组织病理变化.
主要成果:
- 发现ETB无毒 (LD50 > 3000 mg/kg) 并没有影响肝细胞活力.
- 在300mg/kg的剂量下,ETB显著降低了血糖,脂酶活性,总胆固醇和甘油三.
- 根据剂量,ETB改善了氧化应激标志物,并恢复了抗氧化酶活性 (甲酸酶,谷氨过氧化酶,超氧化物脱酶).
- ETB 预防了与 MAFLD 相关的细胞病理性肝损伤.
结论:
- 塔纳塞木香提取物在老鼠中表现出显著的保护作用,防止饮食和链毒素诱导的MAFLD.
- 由于其改善代谢概况和减少氧化应激的能力,ETB显示出作为MAFLD治疗剂的潜力.
- 观察到的好处归因于ETB丰富的植物化学成分,包括酸和黄酸.
关键词:
塔纳塞图姆巴尔萨米塔 (Tanacetum balsamita) 是一种植物.抗氧化剂 抗氧化剂是一种抗氧化剂.代谢综合征代谢综合征代谢相关的脂肪肝疾病肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖氧化应激是一种氧化应激.聚醇是一种多醇.更多相关视频
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