雌激素激素对关节功能障碍的生理病理学的影响
Daniel-Corneliu Leucuța1, Damaris Anton2, Oana Almășan2
1Department of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
Journal of clinical medicine
|August 10, 2024
概括
荷尔蒙因素,特别是雌激素,在女性的部功能障碍 (TMD) 中起着关键作用. 遗传倾向和生殖阶段影响TMD的发展和疼痛.
科学领域:
- 口腔和牙和面部医学
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
背景情况:
- 部功能障碍 (TMD) 包括系统的疾病,导致疼痛和功能障碍.
- 女性比男性更容易患TMD,荷尔蒙因素,特别是雌激素,与其病因有关.
- 荷尔蒙影响和遗传倾向对于理解TMD复杂性质至关重要.
研究的目的:
- 审查当前关于激素因素在部功能障碍中的作用的文献.
- 调查雌激素,遗传因素和TMD发展和严重程度之间的关联.
- 探索生殖生命阶段对TMD发病率和病理学的影响.
主要方法:
- 在PubMed/MEDLINE,Scopus,Embase和Web of Science数据库中进行了全面的文献搜索.
- 在2008年1月至2023年12月期间发表的文章是根据预定义的纳入标准进行选择的.
- 包含的研究的方法质量使用纽卡斯尔-太华尺度和偏差风险工具2进行评估.
主要成果:
- 阿尔法雌激素受体多态性在患有TMD的女性中更为普遍,表明存在遗传联系.
- 雌激素显著影响TMD相关疼痛的病理生理学.
- 患有PCOS的女性表现出较高的TMD发病率,与炎症因素和较低的孕激素水平有关;在绝经前妇女中,β-雌激素水平与TMD相关.
结论:
- 荷尔蒙因素,遗传倾向和生殖阶段对于理解和管理TMD至关重要.
- 将雌激素激素与部功能障碍联系在一起的精确机制需要进一步阐明.
- 未来的研究应该专注于揭开这些协会所涉及的具体途径.
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