口腔微生物组与胃食道逆流严重程度之间的关联
Declan J Power1, Vincent Ho1, Jerry Zhou1
1School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.
Journal of clinical medicine
|August 10, 2024
概括
胃食道逆流性疾病 (GORD) 与口腔微生物组的变化有关. 像Rothia这样的特定细菌减少,而其他细菌则随着反流的严重程度而增加,表明潜在的诊断标志物.
科学领域:
- 微生物组研究 微生物组研究
- 胃肠病学 胃肠病学
- 口腔健康 口腔健康
背景情况:
- 胃食管逆流性疾病 (GORD) 涉及胃中的内容回到食道和口腔,可能导致粘膜损伤.
- 以前的研究将远端食道微生物群的改变与酸性反流的严重程度和GORD进展联系起来.
- 口腔微生物组在GORD中的作用及其与反流严重程度的关联仍然未被探索.
研究的目的:
- 为了研究患有GORD的患者口腔微生物群的变化.
- 为了确定口腔微生物群的变化是否与酸性反流的严重程度相关.
主要方法:
- 收集了58名GORD患者的口水样本,接受了24小时的pH监测.
- 根据DeMeester分数将患者分为正常,轻度和中度/重度反流组.
- 使用16S rRNA基因测序 (V1-V3区域) 分析了口腔微生物的组成和多样性.
主要成果:
- 在反流组之间没有观察到口腔微生物群的整体多样性有显著差异.
- 轻度反流组显示Rothia dentocariosa和Lautropia的减少,而Moryella和Clostridiales的增加_1.1.
- 与对照组相比,中度/严重组的Rothia aeria减少,Schwartzia,Paludibacter,Treponema和T. socranskii增加.
结论:
- 在GORD患者中,口腔微生物组组成存在显著差异,酸性反流的严重程度各不相同.
- 特定细菌种群的丰度与反流的严重程度相关,这表明它们可能是GORD的生物标志物.
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