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气溶采样技术的方法开发和验证,用于分析电子烟气溶中的尼古丁

Maarten Dill¹, Eric Deconinck¹, Sophia Barhdadi¹

¹Sciensano, Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health Products, J. Wytsmanstraat 14, B-1050 Brussels, Belgium.

Molecules (Basel, Switzerland)

|August 10, 2024

概括

一种新方法准确地测量电子烟气溶中的尼古丁,这对于确保产品安全和质量至关重要. 这种经过验证的方法支持国家卫生当局监测日益增长的电子烟市场.

科学领域:

分析化学分析化学
环境健康环境健康

背景情况:

电子烟的普及需要对安全性和质量进行市场监测.
欧盟烟草制品指令要求对电子烟产品进行排放研究.
由于电子烟排放没有经过验证的方法,这阻碍了可靠的分析.

研究的目的:

开发和验证一种用于确定电子烟气溶液中的尼古丁的方法.
确保电子烟排放测量的准确性和可重复性.
为监管合规提供可靠的分析方法.

主要方法:

使用商业蒸汽装置生成电子烟气溶.
在剑桥过器上收集了气溶.
在提取后使用超高性能液体染色学与二极管阵列检测 (UHPLC-DAD) 量化尼古丁.
使用总错误方法和准确性配置文件验证了方法.

主要成果:

准确性概况证实了方法的有效性,β-预期耐受性间隔在±20%的接受限度内.
可重复性和中间精度是可以接受的,最高相对标准偏差 (RSD) 低于5%.
经过验证的方法已成功应用于分析15种商业电子液体中的尼古丁.

结论:

实现了电子烟排放分析方法的完整验证,重点是尼古丁的确定.
开发的方法确保了对监管监督至关重要的可靠测量.
这种系统方法可以适应验证其他电子烟排放分析方法.

关键词:

气溶喷雾剂是一种喷雾剂.电子烟是一种电子烟.方法验证方法的验证方法.尼古丁是一种尼古丁.

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