后生物作为癌症护理中的辅助疗法
Vyshnavy Balendra1, Roberto Rosenfeld2, Chiara Amoroso3
1Saint James School of Medicine, Park Ridge, IL 60068, USA.
Nutrients
|August 10, 2024
概括
来自微生物的后生物,通过调节免疫反应和增强肠道健康,显示出作为辅助癌症治疗的潜力. 然而,不一致的水平和生物可用性限制了当前的临床应用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 后生物制剂是无活化微生物或其成分的制剂,具有健康益处.
- 它们包括各种各样的物质,如代谢物,SCFA和细胞外囊泡.
- 后生物提供潜在的机制来影响致癌,包括免疫调节和细胞毒性.
研究的目的:
- 审查后生物药作为癌症治疗中的辅助疗法的作用.
- 探索后生物质可能影响癌症的机制.
- 讨论后生菌在瘤学中的局限性和未来潜力.
主要方法:
- 文献综述,重点关注后生物药和癌症治疗.
- 分析与致癌发生有关的后生物机制.
- 讨论临床证据和限制.
主要成果:
- 后生物质可以促进免疫平衡,减少炎症,诱导瘤细胞细胞毒性,并增强肠道屏障功能.
- 维生素K是目前在瘤患者中使用的主要后生物药,试验数据有限.
- 不一致的肠道微生物群组成会影响后生物水平,影响生物可用性和疗效.
结论:
- 后生物质药物是癌症治疗的有希望的辅助策略,与化疗和免疫疗法一起.
- 挑战包括生物可用性差,半衰期短和水平可变,需要进一步研究.
- 与单独使用后生菌相比,协生菌可能提供更好的生物可用性和更大的治疗潜力.
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