关节性营养中严重病情的成年人中的甲氨酸和营养状况:前性队列研究
Marcela Almeida Linden1, Renata Germano Borges de Oliveira Nascimento Freitas2, Lidiane Oliveira de Souza Teles1
1Pediatrics Department, State University of Campinas-UNICAMP, Street Tessália Vieira de Camargo, 126, Barão Geraldo, Campinas 13083-887, SP, Brazil.
晶氨酸 (TTR) 水平不能有效地识别营养不良或预测住院患者的结果. 满足热量需求,而不是TTR,与患者的存活率有关,这表明TTR不是可靠的营养标志物.
科学领域:
- 临床营养学 临床营养学
- 生物标志物 生物标志物
- 患者的治疗结果.
背景情况:
- 准确的营养不良评估在临床环境中具有挑战性.
- 晶氨酸 (TTR) 是蛋白质摄入量和营养状况的潜在生物标志物.
- 亲肠道营养 (PN) 需要每天监测是否足够.
研究的目的:
- 评估在住院患者中测量跨甲状腺素 (TTR) 的临床实用性.
- 为了确定TTR水平是否与营养状况和患者的结果相关.
- 评估营养治疗期间常规TTR测量的合理性.
主要方法:
- 研究了一组302名接受PN治疗的住院患者.
- 数据是在三个时间点收集的:在使用PN的72小时内 (T1),第7天 (T2) 和第14天 (T3).
- 与营养状况,热量摄入量和患者的结局进行了对比.
主要成果:
- TTR值与营养状况或患者的结果 (死亡率,营养支持的有效性) 没有关联.
- 满足热量需求与改善患者结果有显著的相关性 (p = 0.047).
- 发现TTR在这个队列中不是营养风险或状态的可靠指标.
结论:
- 晶氨酸 (TTR) 测量对于识别营养不良,预测死亡率或评估住院患者营养支持的有效性是无用的.
- 观察到TTR和C反应蛋白 (CRP) 之间的反向关系,TTR的下降可能表明营养供应无效.
- 这项研究建议专注于热量目标而不是TTR,以优化住院患者的营养治疗.
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