脂肪质量和与肥胖相关的基因依赖性肥胖性编程的风险通过配方养与母乳养相比
Bodo C Melnik1, Ralf Weiskirchen2, Wolfgang Stremmel3
1Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, D-49076 Osnabrück, Germany.
Nutrients
|August 10, 2024
概括
人工配方养可能会改变婴儿的表观遗传编程,通过影响DNA和RNA甲基化,特别是FTO基因,增加肥胖风险. 哺乳促进更健康的表观遗传发育.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 营养编程 营养编程
- 肥胖问题研究研究
背景情况:
- 婴儿养方法 (配方奶粉与母乳养) 可以影响长期的健康结果.
- 表观遗传修饰,包括DNA和RNA甲基化,在发育中起着至关重要的作用.
- 脂肪质量和肥胖相关基因 (FTO) 参与代谢调节和肥胖.
研究的目的:
- 为了比较配方奶粉 (FF) 和母乳养 (BF) 婴儿之间的产后表观遗传编程差异.
- 研究养方法对DNA和RNA甲基化模式的影响.
- 检查养方法,FTO基因表达和肥胖风险之间的关联.
主要方法:
- 对影响FTO基因和蛋白质表达的饮食和表观遗传因素研究的文献综述.
- 关于FTO表达和活动的调节者的翻译证据的分析.
- 调查FTO在产后脂肪生成编程中的作用.
主要成果:
- 配方养 (FF) 与异常的DNA甲基化和FTO基因的增强表达及其RNA脱甲基酶活性有关.
- 蛋白质,酸盐和特定氨基酸等营养成分调节FTO表达和活性.
- 增加FTO信号可能会抑制WNT/β-catenin通路,促进脂肪生成和肥胖.
- 配方诱导的N6-甲基氨酸 (m6A) RNA甲基组的变化与脂肪生成和肥胖有关.
结论:
- 配方养可能导致DNA和RNA甲基化的不良表观遗传变化,可能增加肥胖风险.
- 哺乳 (BF) 支持DNA和RNA甲基化的生理表观遗传调节.
- 需要进一步的研究才能充分理解配方诱导的表观遗传变化及其长期后果.
关键词:
通过DNA甲基化.脂质生成 (adipogenesis) 是一种母乳养 哺乳期 母乳养表观遗传干细胞调节的调节.脂肪质量和肥胖相关基因 (FTO)配方养的养方式m6ARNA甲基化的过程牛奶中的外体miRNAs.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖没有翅膀的信号传输.更多相关视频
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