人类牛奶中的前素取决于分娩方式和性别
Ebe D'Adamo1, Chiara Peila2, Mariachiara Strozzi3
1Neonatal Intensive Care Unit, "G. D'Annunzio" University, 66100 Chieti, Italy.
Nutrients
|August 10, 2024
概括
孕前素 (PSEP) 在人体母乳 (BM) 中可测量,在早产婴儿乳和母乳中更高. 这些发现表明,PSEP可能在早产和早产婴儿的母乳中具有抗菌功能.
科学领域:
- 生物化学 生物化学
- 新生儿研究新生儿研究
- 免疫学 免疫学 免疫学
背景情况:
- 母乳 (BM) 是营养的重要来源,具有抗炎性质.
- 前素 (PSEP) 被认为是早期毒症检测的敏感生物标志物.
研究的目的:
- 为了确定人类母乳中PSEP的存在和水平.
- 分析不同乳汁成熟阶段 (乳母,过渡期,成熟期) 的PSEP度.
- 研究婴儿分娩方式和婴儿性别对PSEP水平的影响.
主要方法:
- 一项多中心前性病例控制研究,涉及44个来自孕期 (T) 和早产 (PT) 婴儿母亲的母乳样本.
- 用化学发光酶免疫试验分析了母乳样本的PSEP度.
- 进行了统计分析,以基于婴儿早产,牛奶成熟阶段,分娩方式和性别来比较PSEP水平.
主要成果:
- 在所有分析的母乳样本中检测到PSEP.
- 在早产婴儿的母亲的牛奶中发现的PSEP度明显高于早产婴儿的母亲的牛奶.
- 大奶粉的PSEP含量高于过渡期和成熟的牛奶.
- 牛奶成熟阶段受到分娩方式和婴儿性别的影响.
结论:
- 人类母乳中存在PSEP,其度随着牛奶成熟和婴儿妊娠状态而变化.
- 母乳中的PSEP水平升高,特别是在乳母乳和早产乳中,可能表明在抗菌防御中发挥作用.
- 需要进一步的研究来阐明PSEP在母乳中的特定功能和影响.
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