相关实验视频

Updated: Jun 21, 2026

Designing Porous Silicon Films as Carriers of Nerve Growth Factor

Designing Porous Silicon Films as Carriers of Nerve Growth Factor

Published on: January 25, 2019

多功能Sr,Mg-Doped Mesoporous生物活性玻璃纳米颗粒用于同时进行骨再生和药物输送

Tamara Matic¹, Farah Daou², Andrea Cochis²

¹Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia.

International journal of molecular sciences

|August 10, 2024

概括

和联合的半孔生物活性玻璃纳米粒子 (SrMg-MBGNs) 显示了双重药物和离子传递的增强性质. 这些生物相容的纳米粒子促进干细胞活性和内皮细胞的增殖,表明生物医学应用的潜力.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
材料化学材料化学

背景情况:

半孔生物活性玻璃纳米颗粒 (MBGNs) 提供药物和治疗离子的双重输送.
用和等离子对MBGN进行兴奋剂可以增强其功能.

研究的目的:

调查与和离子联合兴奋剂对MBGN特性的影响.
评估SrMg-MBGNs的物理化学特性,生物活性和药物输送能力.

主要方法:

修改的微乳液辅助sol-gel合成用于颗粒制造.
对物理化学性质,生物活性和药物加载/释放的评估.
间接生物测定使用人类骨髓衍生中介质干细胞 (hBM-MSCs) 和内皮EA.hy926细胞.

主要成果:

Sr,Mg-doping 增加了孔腔体积和溶解度,改变了中孔结构,略加快了药物释放.
SrMg-MBGNs与hBM-MSCs表现出生物相容性,诱导性酸酶 (ALP) 生产和沉积.
颗粒物显著增强EA.hy926细胞增殖,并影响细胞骨组织,与VEGF刺激相似.

结论:

由于其增强的特性和生物效应,Sr,Mg-MBGNs对生物医学应用具有有前途的特性.
联合兴奋剂策略提供了一种可行的方法,用于设计用于再生医学和药物输送的多功能纳米粒子.

关键词:

3D细胞培养模型在 BM-MSC 测试中.在EA.hy92626中,生物活性玻璃玻璃的使用.离子兴奋剂 - 离子兴奋剂中等度 (mesoporosity) 是指中等度的存在.

更多相关视频

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Published on: April 15, 2022

Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration

Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration

Published on: July 6, 2022

相关概念视频

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...