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升高的LAMTOR4表达与致死性前列腺癌有关,并且其杀降低了细胞增殖,入侵和细胞迁移在体外

Yaser Gamallat^1,2,3, Huseen Alwazan¹, Rasoul Turko¹

¹Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

International journal of molecular sciences

|August 10, 2024

概括

在前列腺癌患者中,高LAMTOR4蛋白表达与较差的生存结果相关. 在前列腺癌细胞中抑制LAMTOR4可减少扩散和转移,这表明它是治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
细胞生物学细胞生物学

背景情况:

拉姆托 (LAMTOR) 复合体 (晚期内体/溶体适配器,MAPK和mTOR) 集成生长因子信号和营养感应.
在瘤发生,特别是前列腺癌中LAMTOR4的特定作用仍然在很大程度上未被探索.
LAMTOR4可能在瘤细胞增殖和转移中发挥作用.

研究的目的:

研究前列腺癌中LAMTOR4的蛋白质表达 (PCa).
为了将LAMTOR4表达与基因组状态 (ERG,PTEN) 和临床病理特征相关联.
在体外探索LAMTOR4在PCa细胞行为和相关途径中的功能作用.

主要方法:

在314个前列腺切除样本中分析LAMTOR4的蛋白质表达.
与ERG和PTEN基因组状态,格里森得分和患者存活率的相关性.
在前列腺癌细胞系中LAMTOR4的体外淘汰和通过TCGA-PRAD进行mRNA表达分析.

主要成果:

高LAMTOR4蛋白表达与较差的整体存活率 (OS) 和因果特异性存活率 (CSS) 显著相关.
结合高LAMTOR4表达与PTEN阴性状态或ERG阳性状态进一步恶化患者的生存结果.
抑制LAMTOR4降低了PCa细胞的增殖,迁移和入侵,并失调了β-catenin/mTOR通路.

结论:

拉姆托尔4是前列腺癌的潜在预后生物标志物.
拉姆托尔4在促进前列腺癌进展和转移方面发挥着重要作用.
准LAMTOR4或mTOR通路为前列腺癌提供了一个潜在的治疗策略.

关键词:

在 ERG ERG 里面,有很多东西可以做.这就是MAPKK的意思.在这里,我们可以使用PTEN.晚期内体/溶体适配器 mTOR激活器4 (LAMTOR4) 的使用猛素的哺乳动物标 (mTOR)

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