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Updated: Jun 17, 2025

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
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基于综合生物信息的识别和验证与神经炎症相关的核心基因在初级开放角眼中

Zakir Ullah1, Yuanyuan Tao1, Jufang Huang1

  • 1Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha 410013, China.

International journal of molecular sciences
|August 10, 2024
PubMed
概括

这项研究确定了六个关键的神经炎症基因,这些基因与原发性开角玻璃眼 (POAG) 有关. 三个基因,SERPINA3,IL1R1和LCN2,显示出希望作为青光眼患者的诊断生物标志物.

关键词:
生物信息学分析分析不同表达的基因.核心基因 核心基因 核心基因神经炎症是一种神经炎症.主要的开放角度眼光.

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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