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Updated: Jun 17, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
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Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

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抑制剂和5-脂氧酶之间的相互作用:高斯加速分子动力学和马尔科夫状态模型的见解

Yuyang Liu1, Kaiyu Wang1, Fuyan Cao2

  • 1Edmond H. Fischer Signal Transduction Laboratory, School of Life Sciences, Jilin University, Changchun 130012, China.

International journal of molecular sciences
|August 10, 2024
PubMed
概括

这项研究揭示了天然化合物Nordihydroguaiaretic acid (NDGA) 和3--11-keto-β-boswellic acid (AKBA) 如何抑制5-lipoxygenase (5LOX) 的作用. NDGA竞争性地阻断了活性部位,而AKBA则全osterically改变了酶构造,影响了炎症途径.

关键词:
5 - 脂氧基因酶的使用.在 GaMD GaMD 中.马尔科夫状态模型的模型.全osteric 抑制的抑制.

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors10:33

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