相关实验视频
Updated: Jun 17, 2025

09:11
In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
Published on: June 8, 2022
2.2K
氧化化学:对死性肠球炎的影响
Grant H Gershner1,2, Catherine J Hunter1,2
1Division of Pediatric Surgery, Oklahoma Children's Hospital, 1200 Everett Drive, ET NP 2320, Oklahoma City, OK 73104, USA.
International journal of molecular sciences
|August 10, 2024
概括
氧化应激 (OS) 发生在身体过度生产反应性氧和物种时,压倒了抗氧化系统. 本综述探讨了氧化还原化学及其与新生儿死性肠球炎 (NEC) 的联系.
科学领域:
- 生物化学 生物化学
- 新生儿生理学 新生儿生理学
- 病理生理学 病理生理学
背景情况:
- 降解氧化 (redox) 化学是人类平衡的基础,涉及能源生产,免疫力和细胞信号传递.
- 导致反应性氧物种 (ROS) 和反应性物种 (RNS) 过度产生的不平衡会导致氧化应激 (OS).
- 在新生儿中,OS与早产视网膜病变 (ROP),白血病和支气管肺功能失调 (BPD) 等疾病有关.
研究的目的:
- 解释氧化还原化学和内源性抗氧化机制的基本原理.
- 讨论不受控制的氧化还原失衡的病理后果,特别是氧化应激.
- 检查氧化应激在新生儿死性肠球炎 (NEC) 中的潜在作用.
主要方法:
- 对氧化还原化学原理的文献综述.
- 对生理学抗氧化剂系统的讨论.
- 探索氧化应激机制及其对新生儿健康的影响,重点关注NEC.
主要成果:
- 氧化还原反应对于正常的生理功能至关重要.
- 氧化应激源于ROS/RNS生产和抗氧化防御之间的不平衡.
- 新出现的证据表明,OS在新生儿NEC的发病过程中发挥了作用.
结论:
- 了解氧化还原平衡对于理解细胞功能和疾病至关重要.
- 氧化应激是新生儿发病的重要危险因素,包括NEC.
- 需要进一步的研究来阐明OS与NEC联系的具体机制,并开发有针对性的干预措施.
相关概念视频
Redox Equilibria: Overview
545
A reduction-oxidation reaction is commonly called a redox reaction. In a redox reaction, electrons are transferred from one species to another rather than being shared between or among atoms. The reducing agent or reductant is the species that loses electrons and gets oxidized in the process. The species that gains electrons and gets reduced in the process is the oxidizing agent or oxidant. Redox reactions are represented as two separate equations called half-reactions, where one equation...
545
Necrosis
4.4K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.4K
Oxidation-Reduction Reactions
64.6K
Oxidation–Reduction Reactions
64.6K
Electron Transport Chain: Complex I and II
12.5K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
12.5K
Phase I Reactions: Reductive Reactions
194
Phase I biotransformation reductive reactions are chemical processes that modify drugs by introducing or revealing polar functional groups via reduction. Enzymes called reductases catalyze these reactions, playing a pivotal role in drug metabolism by transforming lipophilic drugs into more polar, water-soluble metabolites for easy excretion. An essential type of reductive reaction is the carbonyl group reduction, where aldehydes and ketones are reduced to alcohols. An example is the...
194
Electrolysis
26.2K
In a galvanic cell, the electrical work is done by a redox system on its surroundings as electrons produced by the spontaneous redox reactions are transferred through an external circuit. Alternatively, an external circuit does work on a redox system by imposing a voltage sufficient to drive an otherwise nonspontaneous reaction in a process known as electrolysis. For instance, recharging a battery involves the use of an external power source to drive the spontaneous (discharge) cell reaction in...
26.2K

