细胞因子和精神分裂症之间的相互关系:系统性审查
Haibing Lv1, Meng Guo2, Chuang Guo1
1College of Life Sciences and Food Engineering, Inner Mongolia Minzu University, Tongliao 028000, China.
International journal of molecular sciences
|August 10, 2024
概括
细胞外囊泡 (EV) 中的细胞因子 (CK) 显示出潜力作为精神分裂症 (SCZ) 的生物标志物. 本综述探讨了它们在SCZ病原和诊断中的作用,为改进的诊断工具提供了希望.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 精神分裂症 (SCZ) 由于其患病率和残疾影响而构成重大全球健康挑战.
- 目前的SCZ诊断严重依赖于主观症状报告,因为缺乏明确的病因学理解和可靠的生物标志物.
- 新出现的证据表明,炎症反应,特别是血液和脑脊液 (CSF) 中细胞因子 (CK) 水平的改变,在SCZ病变发生过程中起着作用.
研究的目的:
- 综合审查细胞因子 (CKs) 和精神分裂症 (SCZ) 之间的关系.
- 突出封装在细胞外囊泡 (EVs) 中的CKs作为SCZ的诊断生物标志物的潜力.
- 阐明EV封装的CK在SCZ的发病和进展中的作用.
主要方法:
- 文献综述综合了关于细胞因子,细胞外囊泡和精神分裂症的现有研究.
- 对调查SCZ患者周围血液和脑脊液中细胞因子水平的研究进行分析.
- 检查细胞外囊泡在隔离和运输疾病特异性分子,包括细胞因子中的作用.
主要成果:
- 在SCZ患者中经常观察到各种细胞因子 (CK) 的异常水平,这表明炎症和疾病之间存在联系.
- 细胞外囊泡 (EVs),特别是来自免疫细胞的囊泡,含有CKs,并与疾病相关的细胞间通信有关.
- 电动汽车中CK的稳定性和丰富性使它们成为开发新型SCZ生物标志物的有希望的候选者.
结论:
- 封装在细胞外囊泡 (EVs) 中的细胞因子 (CKs) 代表了理解SCZ病变的重要研究领域.
- 来自EV的CK具有相当大的前景,作为稳定和可访问的生物标志物,可以改善精神分裂症的诊断和监测.
- 对EV-CK的进一步调查可能会导致开发客观的诊断工具,克服当前主观评估的局限性.
更多相关视频
相关概念视频
Biological Causes of Schizophrenia
51
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
51
Psychological and Sociocultural Causes of Schizophrenia
81
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
81
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
541
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
541
Schizophrenia
72
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
72
Psychosis and Antipsychotic Drugs: Overview
213
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
213
Negative and Cognitive Symptoms of Schizophrenia
46
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
46


