探索长非编码RNA的实用性,以评估电子烟对健康的影响
Ahmad Besaratinia1, Hannah Blumenfeld1, Stella Tommasi1
1Department of Population & Public Health Sciences, USC Keck School of Medicine, University of Southern California, M/C 9603, Los Angeles, CA 90033, USA.
International journal of molecular sciences
|August 10, 2024
概括
电子烟 (e-cig) 使用,或vaping,是常见的,但长期的健康影响是未知的. 长非编码RNAs (lncRNAs) 可能会显示出vaping.
科学领域:
- 表观遗传学和基因调控
- 分子生物学分子生物学
- 公共卫生 公共卫生
背景情况:
- 在青少年和成年人中,电子烟 (e-cig) 使用或vaping很普遍.
- 电子烟的长期健康后果在很大程度上是未知的.
- 表观遗传修饰,特别是涉及长非编码RNA (lncRNAs),与吸烟相关的疾病有关.
研究的目的:
- 审查电子烟技术的演变和安全性争议.
- 总结目前关于lncRNAs在电子烟相关基因失调中的作用的研究.
- 确定关于电子烟和公共卫生的知识差距和未来研究重点.
主要方法:
- 关于电子烟技术,使用趋势和安全数据的文献综述.
- 对研究蒸汽中 lncRNA 功能的研究进行分析.
- 在蒸汽器和体外模型中对lncRNA介导的基因调节的研究综合.
主要成果:
- 有限的研究表明,IncRNAs在vapers中调解基因失调.
- lncRNAs是健康和疾病中的基因表达的关键调节者.
- 电子烟可能通过涉及lncRNAs的表观遗传机制影响与疾病相关的基因.
结论:
- lncRNAs是评估电子烟致病潜力的新兴生物标志物.
- 进一步的研究至关重要,以了解电子烟的健康风险,并为监管提供信息.
- 关于lncRNA调制的实证数据对于有关电子烟的公共卫生政策至关重要.
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