血清25-基维生素D和初级结肠癌的五年生存率:一个回顾性队列研究
1School of Medicine, University of California, San Diego, CA, USA.
Nutrition and cancer
|August 10, 2024
概括
较高的维生素D水平 (25-氧维生素D) 与结肠癌患者的死亡率降低有关. 维持最佳维生素D水平可能会改善被诊断患有这种疾病的个体的生存结果.
科学领域:
- 在瘤学瘤学.
- 营养生物化学 营养生物化学
- 流行病学 流行病学
背景情况:
- 血清25-基维生素D (25(OH) D是维生素D状态的关键指标.
- 维生素D在癌症进展和患者生存中的作用是积极研究的领域.
- 结肠癌的预后可能受到各种患者特异性因素的影响.
研究的目的:
- 研究结肠癌患者诊断后血清25(OH) D水平与5年死亡率之间的关联.
- 为了确定是否存在剂量反应关系或25(OH) D对结肠癌存活率的值效应.
- 评估维生素D补充或纠正该患者群体缺陷的潜在保护作用.
主要方法:
- 利用加利福尼亚大学的临床数据库,分析了1,602名结肠癌患者的数据.
- 诊断后至死亡或5年后计算的血清中平均25...OH) D水平.
- 在统计分析中使用了通用增量模型 (GAM),逻辑回归和Cox比例危险模型.
主要成果:
- 在更高的诊断后25(OH) D水平和5年死亡率 (OR = 0.79,HR = 0.94) 之间发现了显著的反向关联.
- 在调整了疾病严重程度和人口统计因素后,这种关联仍然显著.
- GAM分析表明,生存益处停滞在大约50.0 ng/mL的25(OH) D.
结论:
- 血清25(OH) D水平升高与结肠癌患者的生存率改善有关.
- 纠正维生素D缺乏 (低于25 ng/mL) 和目标水平高于50 ng/mL可能对结肠癌患者的治疗结果有益.
- 维生素D可能在结肠癌患者的生存中起到保护作用.
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