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在患有焦虑症患者的随机对照试验中,盲目的完整性和药物疗效之间的关系:系统性审查和元分析
Ruqayyah Haq1, Laura Molteni2,3, Nathan T M Huneke1,2,3
1Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Acta psychiatrica Scandinavica
|August 10, 2024
概括
在焦虑障碍试验中,盲目诚信很少被评估. 当评估时,它经常失败,可能会膨胀治疗效果大小,特别是在未盲目的临床医生或安慰剂组的患者中.
科学领域:
- 精神病学是一个精神病学.
- 临床试验 临床试验
- 心理药理学 心理药理学
背景情况:
- 双盲随机对照试验 (RCT) 中的失明旨在最大限度地减少偏差.
- 讨论了评估和报告RCT中盲目完整性的必要性.
- 失明失败对焦虑症治疗结果的影响在很大程度上是未知的.
研究的目的:
- 系统地审查焦虑缓解性RCT中失明完整性的评估和报告.
- 探索盲目完整性与焦虑症治疗疗效之间的关联.
主要方法:
- 对成年人抗焦虑药物的安慰剂对照随机试验的系统审查 (1980年至今).
- 提取关于遮完整性和治疗疗效的数据.
- 使用Cochrane工具评估偏差风险,并计算Bang's盲目指数.
- 统计分析了遮完整度和治疗效果大小之间的关联.
主要成果:
- 在包括的247个RCT中,只有3.64%的RCT提供了盲目的完整性评估.
- 在评估的试验中,55.56%的失明失败,尽管80%的安慰剂手臂保持了失明.
- 在评估器中,降低失明完整性与较大的治疗效果大小相关 (p < 0.001).
- 一个不显著的趋势显示,安慰剂组的失明完整性降低,与患者报告的疗效增加有关.
结论:
- 失明完整性在焦虑缓解RCT中很少被报告,并且在评估时经常失败.
- 临床医师评估人员和安慰剂组患者的潜在失明可能与更大的治疗效果大小有关.
- 对于焦虑缓解性RCT,建议系统地收集盲目完整性数据和对组分配信念的原因.
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