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通过高压氧介导的PI3K/Akt/mTOR途径,在下大脑下出血后抑制延迟脑血管

Bingxue Liu¹, Li Zhang², Dapeng Xu³

¹Department of Pediatric Neurosurgery, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, 214023, Jiangsu, China.

Cell biochemistry and biophysics

|August 10, 2024

概括

高压氧化 (HBO) 有效地治疗脑下下出血 (SAH) 后的延迟脑血管 (CVS). 通过调节PI3K/Akt/mTOR通路,HBO治疗可以改善神经功能并减少血管.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
药理学药理学是指药理学的学科.

背景情况:

延迟大脑血管 (CVS) 是下大脑下出血 (SAH) 后的一个关键并发症.
了解CVS背后的机制对于开发有效的治疗方法至关重要.

研究的目的:

在SAH后延迟的CVS上研究高压氧化 (HBO) 的抑制机制.
探索PI3K/Akt/mTOR途径在HBO治疗效果中的作用.

主要方法:

建立一个小鼠模型下arachnoid出血 (SAH).
使用修改后的加西亚尺度评估神经功能.
通过Western blot分析PI3K/Akt/mTOR通路蛋白质.
使用TUNEL测定对内皮细胞亡的评估.
使用HE染色对大脑动脉进行组织学检查.

主要成果:

在SAH大鼠中,HBO治疗显著改善了神经功能.
HBO增加了Bcl-2,PI3K,mTOR和p-Akt/Akt的血水平.
HBO降低了巴克斯蛋白的血水平和心血管硬化程度.
mTOR表达与CVS的严重程度有负相关性.

结论:

高压氧化 (HBO) 有效地抑制了脑下下出血 (SAH) 后的延迟脑血管 (CVS).
HBO通过调节PI3K/Akt/mTOR信号通路来发挥其保护作用.
HBO治疗为管理SAH后并发症提供了一个有前途的治疗策略.

关键词:

延迟的CVS时间在HBO上,HBO就是HBO.在PI3K/Akt/mTOR路径中.萨赫 (SAH) 是一个国家.

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