在患有复发的患者中,腹膜扩散在 Pleural mesothelioma 后的多叶切除术/脱皮术后复发
Akifumi Nakamura1, Masaki Hashimoto2, Ayumi Kuroda2
1Division of Thoracic Surgery, Department of Surgery, Hyogo Medical University, Nishinomiya, Hyogo, Japan. xxmp97511@zeus.eonet.ne.jp.
Annals of surgical oncology
|August 10, 2024
概括
腹膜扩散发生在12.5%的患者中,在手术后患有复发性多性间皮瘤. 这种与女性性别和隔膜重建相关的复发模式,显著恶化了生存结果.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 间皮瘤研究 间皮瘤研究
背景情况:
- 腹膜扩散是一种不常见的复发模式,在治疗性意图的手术后用于多叶膜间皮瘤.
- 这种特定复发的风险因素和预后没有得到充分的记录.
研究的目的:
- 为了调查发生率,风险因素,并在多切除/脱皮后对多间皮瘤进行腹膜扩散的预后影响.
主要方法:
- 160名患有复发性多叶膜间皮瘤后多叶切除术/脱皮术的患者的回顾性审查.
- 分类为腹传播 (P组) 和非腹传播 (非P组) 组.
- 风险因素的多变量逻辑回归和Kaplan-Meier/log-rank测试用于生存分析.
主要成果:
- 20名患者 (12.5%) 患有腹传播 (P组).
- 隔膜重建 (OR 2.8) 和女性性别 (OR 3.7) 是围传播的重要风险因素.
- 而P组的复发后存活时间明显较差 (中位数为6.7个月与19.4个月).
结论:
- 腹膜扩散影响了大约12.5%的复发性多叶膜间皮瘤患者.
- 女性性别和腹膜重建与风险增加有关.
- 术后腹膜扩散表明预后不佳.
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