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营养干预对接受新辅助化学放射治疗的癌症患者的影响:随机对照试验的元分析
Chunrong Li1, Shu Zhang1, Yan Liu1
1Department of Critical Care, West China Hospital, Sichuan University, No. 363, Section 3, Furong Avenue, Wenjiang District, Chengdu, 611100, China.
概括
在接受新辅助化疗或放射治疗的癌症患者中,营养干预显著减少吐和粘膜炎等副作用. 这些干预措施还改善了营养状况,缩短了住院时间,改善了患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 临床营养学 临床营养学
- 基于证据的医学基于证据的医学.
背景情况:
- 癌症患者中普遍存在营养不良,对生活质量和生存有负面影响.
- 新辅助化学辐射疗法 (CRT) 是关键的治疗阶段,营养状况经常受到损害.
研究的目的:
- 系统地审查和元分析营养干预措施对接受新辅助CRT的患者的影响.
- 评估对治疗毒性,营养状况和临床结果的影响.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行了系统的文献搜索.
- 包括随机对照试验 (RCT) 评估了毒性,炎症标志物,营养状况和临床结果.
- 使用相对风险 (RR) 或加权平均差异 (WMD) 计算效应大小,并使用95%的置信区间 (CI).
主要成果:
- 营养干预显著降低了吐 (RR=0.37) 和粘膜炎 (RR=0.82) 的发生率.
- 观察到营养良好患者的显著增加 (RR=12.74).
- 手术后住院时间减少 (WMD=-0.82天).
结论:
- 营养干预措施有效地减轻了新辅助CRT毒性 (吐,粘膜炎).
- 这些干预措施改善了患者的营养状况,并减少了术后住院时间.
- 需要进一步进行高质量的研究,以优化癌症患者的营养策略.
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