最近在COVID-19引起的肝损伤方面的进展:原因,诊断和管理
Samar A Antar1,2, Nada A Ashour3, Amir O Hamouda4
1Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, VA, 24016, USA.
Inflammopharmacology
|August 10, 2024
概括
COVID-19 (SARS-CoV-2) 显著影响肝脏健康,特别是在慢性肝病 (CLD) 患者中. 这篇评论详细介绍了病毒的细节.
科学领域:
- 肝病学和病毒学.
- 传染性疾病 传染性疾病
- 内部医学 内部医学
背景情况:
- 由SARS-CoV-2引起的COVID-19呈现出影响多个器官系统的多种临床症状.
- 患有先前存在的慢性肝病 (CLD) 的患者在感染SARS-CoV-2时面临更高的风险,包括肝衰竭和死亡率.
- 了解SARS-CoV-2和肝脏健康之间的复杂关系对于管理肝脏病患者至关重要.
研究的目的:
- 在肝脏健康的背景下,审查SARS-CoV-2感染的特征,机制和临床影响.
- 检查肝脏生物化学作为COVID-19诊断工具的潜力.
- 探索大流行对患者行为和肝脏病学服务的影响.
主要方法:
- 关于SARS-CoV-2,COVID-19及其对肝系统的影响的综合文献综述.
- 对专注于慢性肝病 (CLD) 患者SARS-CoV-2感染的研究进行分析.
- 对肝细胞的直接病毒感染和肝损伤途径的研究评估.
主要成果:
- SARS-CoV-2 感染与肝硬化患者肝脏衰竭和死亡风险的增加有关.
- 肝脏生物化学可以作为COVID-19患者的诊断指标.
- 疫情已经显著改变了患者的行为和肝脏病学服务,可能会恶化肝脏疾病的结果.
结论:
- SARS-CoV-2 对肝脏健康构成重大风险,特别是在已经存在的慢性肝炎患者中.
- 需要进一步的研究来阐明对肝脏的直接病毒影响,并开发向疗法.
- 疫情对肝病发病率和严重程度的长期影响需要持续监测和管理策略.
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