根据SNOT-22得分报告的慢性鼻炎的严重程度的性别差异
Snehitha Talugula1, Richard Chiu1, Sharmilee M Nyenhuis2
1University of Illinois College of Medicine, 1853 W Polk St, Chicago, IL 60612, USA.
American journal of otolaryngology
|August 10, 2024
概括
患有鼻息息肉性慢性鼻炎 (CRSwNP) 的女性报告的症状比男性更严重. 虽然在统计学上并不显著,但这种趋势表明性别可能会影响CRSwNP的严重程度,因此需要进一步调查潜在的荷尔蒙因素.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 带鼻息肉的慢性鼻炎 (CRSwNP) 是一种常见的疾病,严重程度的性别差异不明.
- 现有研究表明,喘和过敏呼吸道疾病的性别差异可能与荷尔蒙影响有关.
- 有限的研究已经探索了性别在CRSwNP严重性方面的特定作用.
研究的目的:
- 调查性别与CRSwNP严重程度之间的关联.
- 根据性别分析与CRSwNP相关的生活质量结果的差异.
- 为了解CRSwNP中潜在的性别特异性病原体做出贡献.
主要方法:
- 利用了NAVIGATE I和II随机对照试验 (OPTINOSE数据库) 181名参与者的数据.
- 分析了SNOT-22分数作为CRSwNP严重程度和生活质量的主要结果.
- 采用多重线性回归,控制喘,种族和种族等并发症,以评估性别和SNOT-22分数之间的关联.
主要成果:
- 总共有81名女性和100名男性被纳入分析.
- 与男性相比,女性报告SNOT-22得分显著更高 (平均53.8±16.5),平均为46.8±18.8).
- 调整后的回归分析显示,性别与SNOT-22分数之间的关联接近,但没有达到统计学意义 (p=0.09).
结论:
- 女性往往会比男性更严重地经历CRSwNP的表现.
- 观察到的趋势表明性别在CRSwNP严重性方面可能发挥作用,接近统计学意义.
- 建议进行进一步的研究,包括荷尔蒙调查,以充分了解性别对CRSwNP病变的影响.
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