,身体活动和益生菌在刺激性肠综合征管理中的相互作用:一项双盲随机研究
Wei-Cheng Chao1, Jen-Chieh Huang2, San-Land Young3
1Ph.D. Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung, Taiwan.
Complementary therapies in clinical practice
|August 10, 2024
概括
这项研究发现,将在线,正念和益生菌结合起来,显著改善了刺激性肠综合征 (IBS) 患者的身体健康和生活质量. 该干预措施还积极改变了肠道微生物群的组成,为管理IBS提供了全面的方法.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 综合医学是一个整体的医学.
背景情况:
- 刺激性肠综合征 (IBS) 是一种复杂的胃肠疾病.
- 当前的管理策略往往会产生低于最佳的结果.
- 肠-肌肉-大脑轴越来越多地被认为在IBS病理生理学中的作用.
研究的目的:
- 调查在线,正念和益生菌对IBS的协同效应.
- 评估对身体健康,心理健康和肠道微生物群的影响.
- 探索IBS症状管理的多方面的方法.
主要方法:
- 一个为期六周的随机,双盲,安慰剂对照试验.
- 31名IBS患者被分为三个组:使用益生菌的在线 (EP),使用安慰剂的在线 (EC) 和仅使用益生菌 (P).
- 评估包括体能测试,生活质量 (IBS-QOL),心理健康 (BSRS-5) 和通过便样本进行肠道微生物组分析.
主要成果:
- 在EP组,心血管耐力改善 (P < 0.001) 和克莱布西拉减少 (P < 0.05).
- 在EP和EC组,IBS-QOL分数显著改善 (P<0.001和P<0.05),表明生活质量有所提高.
- 虽然心理健康分数 (BSRS-5) 在两组中都下降,但这种变化在统计学上并不显著.
结论:
- 整合在线,正念和益生菌为IBS患者提供了全面的好处.
- 这种干预可以提高身体健康,心理健康,并积极调节肠道微生物群.
- 这些发现强调了针对肠-肌肉-大脑轴的多面性方法的潜力,以有效地管理IBS.
相关概念视频
Irritable Bowel Syndrome III: Medical and Nursing Management
189
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
189
Irritable Bowel Syndrome I: Introduction
264
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
264
Drugs for Treatment of Constipation-Predominant IBS
149
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
149
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
154
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
154
Drugs for Treatment of Diarrhea-Predominant IBS
156
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
156


