奇桑德拉chinensis lignans调节并与内源性大麻素系统合作,以改善与抑郁症相关的肠壁损伤
Jinyu Wang1, Aijuan Zheng1, Fei Lin1
1Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
奇桑德拉中华 (SCL) 通过内源性大麻素系统改善肠道屏障损伤 (IBI) 来缓解抑郁症. 在SCL降低了安纳米德 (AEA) 水平以抑制细胞亡,并激活了大麻素受体2型 (CB2R) 以减少炎症.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 奇桑德拉中国 (Schisandra chinensis lignan,SCL) 通过减轻肠道屏障损伤 (IBI),减少炎症和提供神经保护,表现出抗抑郁作用.
- SCL调节内源性大麻素系统,这是一种涉及抑郁症发病和进展的途径.
研究的目的:
- 探索一种新的抑郁症治疗策略,重点是通过内源性大麻素系统减轻IBI.
- 阐明SCL发挥抗抑郁作用的具体机制.
主要方法:
- 在小鼠中进行行为分析,以评估类似抑郁的行为.
- 组织学和免疫光技术来评估IBI.
- 网络药理学,西部涂抹和LC-MS来分析分子通路,蛋白质表达和内分泌胺水平.
主要成果:
- 治疗SCL改善了类似抑郁症的行为,改善了IBI,与抗炎和抗丧作用有关.
- 胺 (AEA) 水平与炎症和亡正相关;URB-597 (FAAH抗剂) 逆转了SCL的有益作用.
- 通过重新激活MAPK/NF-κB炎症通路,AM630 (CB2R抗剂) 阻止了SCL的IBI改善.
结论:
- 通过调节内源性大麻素系统,SCL可以缓解与抑郁症相关的IBI.
- 在SCL上调节FAAH,降低AEA水平以抑制结肠细胞亡.
- SCL激活CB2R,减少炎症并进一步缓解IBI.
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