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焦虑的多个面孔:额叶的视角
Angela C Roberts1, Kevin G Mulvihill1
1Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK.
Trends in neurosciences
|August 10, 2024
概括
焦虑障碍涉及前额皮质 (PFC) 和前带皮质 (ACC) 的调节失调. 不同的额叶皮质失调模式可能解释焦虑症治疗反应的多样性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 比较心理学比较心理学
背景情况:
- 焦虑症与前额叶皮层 (PFC) 和前带皮层 (ACC) 显著失调有关.
- 焦虑症治疗的成功率是可变的,大约三分之一的患者表现出耐药性.
- 了解焦虑的神经基础对于改善治疗结果至关重要.
研究的目的:
- 调查额叶皮层调节失调的不同模式如何导致焦虑障碍的不同临床表现和治疗反应.
- 探索前额叶中人类和非人类灵长类动物之间威胁调节机制的相似之处.
- 将研究结果与"掠夺性临近连续性"模型和情绪调节的执行功能理论相结合.
主要方法:
- 审查现有的人类和非人类灵长类神经成像以及对焦虑症的临床研究.
- 与威胁处理相关的前额叶皮质功能组织的比较分析.
- 理论上将发现纳入已建立的情感和威胁模型.
主要成果:
- 在人类和非人类灵长类动物的额叶中,威胁调节的功能组织存在显著的相似之处.
- 截然不同的额叶皮层失调的形式可能是焦虑的不同表现的基础.
- 执行功能在产生和调节对威胁的情绪反应方面发挥着核心作用.
结论:
- 焦虑症治疗反应的变化可能源于各种前皮层失调模式.
- "掠夺性迫在眉连续"为了解前额叶在威胁调节中的功能提供了一个有用的框架.
- 对特定的额叶皮质电路的进一步研究可能会导致更加个性化的焦虑症治疗方法.
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