肥胖与全身免疫炎症指数之间的关联,美国成年人中的全身炎症反应指数:基于人口的分析
Yaoyao Zhou1,2, Yaqi Wang1,2, Taotao Wu1,2
1College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310051, China.
Lipids in health and disease
|August 10, 2024
概括
肥胖与炎症有关. 这项研究发现,系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 的较高水平与美国成年人的肥胖有关.
科学领域:
- 医学研究 医学研究
- 炎症和免疫学 炎症和免疫学
- 公共卫生 公共卫生
背景情况:
- 肥胖是一种慢性疾病,与轻度炎症有关.
- 系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 是新兴的炎症生物标志物.
- 肥胖与这些炎症指数之间的关系尚未得到充分证实.
研究的目的:
- 在美国成年人群中调查肥胖与SII和SIRI之间的关联.
- 探索潜在的非线性关系和子组相互作用.
主要方法:
- 对20 011名成年人的国家健康和营养检查调查 (NHANES) 数据 (2011-2018) 的分析.
- 将SII,SIRI和SII-SIRI分为三种类型的分类.
- 多变量逻辑回归和受限立方线 (RCS) 分析.
- 分析子组以探索相互作用.
主要成果:
- 39.32%的参与者被归类为肥胖.
- 较高的SII,SIRI和SII-SIRI水平与肥胖有显著的相关性.
- 限制性立方脊线分析表明,肥胖和SII/SIRI之间存在非线性关联.
- 观察到SII/SIRI与年龄之间的相互作用.
结论:
- 肥胖与美国成年人的SII,SIRI和SII-SIRI有关.
- 这些指数可能为评估肥胖提供一种具有成本效益的方法.
- 进一步的研究可能会探索SII/SIRI在肥胖管理中的临床实用性.
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