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在非糖尿病患者中,心脏自主功能受损,患有1小时后负载高血糖症:一个横截面研究
Giuseppe Monea1, Raffaele Jiritano1, Luca Salerno1
1Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
在口服葡萄糖耐受性测试 (OGTT) 中,血葡萄糖水平升高1小时 (1hPG) 表明心脏自主功能受损. 这一发现突出了一个新的糖尿病前期类别,患心血管问题的风险增加.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 心脏自主功能障碍与胰岛素抵抗障碍,如肥胖,葡萄糖耐受性损失 (IGT) 和2型糖尿病有关.
- 在口服葡萄糖耐受性测试 (OGTT) 中,高一小时血葡萄糖 (1hPG) 水平 (≥155 mg/dl) 确定了糖尿病前期类别 (NGT 1h-high) 的心血管风险增加.
研究的目的:
- 为了研究1小时后负载高血糖和心脏自主功能障碍之间的关联.
- 确定1hPG是否是心脏自主神经病变 (CAN) 和心率变化 (HRV) 减少的独立预测因素.
主要方法:
- 评估心脏自主神经病变 (CAN) 使用心血管自主反射测试 (CART) 和心率变化 (HRV) 通过24小时心电图.
- 评估了88名非糖尿病患者,根据OGTT结果进行分类:正常葡萄糖耐受 (NGT) 低1hPG (NGT 1h-low),NGT高1hPG (NGT 1h-high) 和IGT.
主要成果:
- 与NGT 1h-high和IGT的受试者相比,与NGT 1h-low相比,他们表现出更高的CAN率和降低的HRV参数.
- 1hPG,不是禁食或2小时PG,与CAN和HRV有显著的关联.
- 多变量分析证实1hPG是HRV和CAN存在的独立预测因子.
结论:
- 具有1hPG≥155 mg/dl的个体表现出心脏自主功能受损.
- 这一1hPG值确定了与自主功能障碍和潜在心血管风险相关的糖尿病前期状态.
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