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Updated: Jun 17, 2026

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新一代的SARS-CoV-2抗体CDRH3与预先训练的生成性大语言模型

Haohuai He1,2, Bing He3, Lei Guan4

  • 1AI Lab, Tencent, Shenzhen, 518052, China.

Nature communications
|August 10, 2024
PubMed
概括

我们开发了PALM-H3,这是人工智能模型,用于新的抗体生成,减少对天然抗体的依赖. 生成的抗体显示出高结合亲和力和对抗SARS-CoV-2变体的中和.

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Coronavirus01:29

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Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...